Pharmaceutical Intermediate Ceritinib Raw Material Ceritinib Powder Ceritinib
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Product Details
| Customization: | Available |
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| Powder: | Yes |
| Customized: | Customized |
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Basic Info.
- Model NO.
- CQM Ceritinib
- Certification
- GMP, HSE, ISO 9001, USP, BP
- Suitable for
- Elderly, Adult
- State
- Powder
- Purity
- >99%
- Product Name
- Ceritinib
- Name
- Ceritinib Powder
- Appearance
- White Powder
- Color
- White
- Grade
- Pharmaceutical Grade
- Assay
- HPLC 99%
- Application
- Pharmaceutical
- Specific
- COA
- Test Method
- HPLC
- Shelf Life
- 2 Years
- CAS No.
- 1032900-25-6
- Mf
- C28h36cln5o3s
- MW
- 558.14
- Melting Point
- 720.7
- Density
- 1.251
- Transport Package
- Negotiable
- Specification
- 99%
- Trademark
- CQM
- Origin
- Shaanxi Xi'an
- Production Capacity
- 1000kg/Month
Product Description
Pharmaceutical Intermediate Ceritinib Raw Material Ceritinib Powder Ceritinib
Product Description
Product Details
Product Name | Ceritinib |
CAS No. | 1032900-25-6 |
MF | C28h36cln5o3s |
MW | 558.14 |
Appearance | White Powder |
Ceritinib, with the Chemical Abstracts Service (CAS) number 1032900-25-6, is a small-molecule tyrosine kinase inhibitor that specifically targets anaplastic lymphoma kinase (ALK). It is chemically known as 5-Chloro-N2-[2-isopropoxy-5-methyl-4-(4-piperidinyl)phenyl]-N4-[2-(isopropylsulfonyl)phenyl]-2,4-pyrimidinediamine. The molecular formula of ceritinib is C28H36CIN5O3S, and it has a molecular weight of 558.14 g/mol. Ceritinib appears as a white to off-white powder with low solubility in aqueous solutions but higher solubility in organic solvents like dimethyl sulfoxide (DMSO). It is stable under standard storage conditions but should be protected from light and moisture to maintain its integrity. Ceritinib is a potent and selective inhibitor of ALK, with additional activity against factor 1 receptor (IGF-1R) and ROS1 kinase. Its mechanism of action involves binding to the ATP-binding site of ALK, thereby inhibiting its phosphorylation and downstream signaling pathways, which are critical for the survival and proliferation of cancer cells.
Application&Function
Ceritinib is primarily used in the treatment of non-small cell lung cancer (NSCLC) that is ALK-positive, as identified by FDA-approved tests. It is particularly effective in patients who have developed resistance to crizotinib, another ALK inhibitor. Ceritinib works by blocking the aberrant ALK signaling that drives tumor growth, leading to apoptosis in cancer cells. Clinical trials have demonstrated its efficacy in both treatment-naïve and crizotinib-resistant patients, with significant tumor response rates and progression-free survival benefits. The drug is administered orally, typically in the form of capsules, and is metabolized primarily by the liver via cytochrome P450 enzymes, particularly CYP3A4. Due to its potent inhibitory effects, ceritinib has also shown promise in treating other ALK-driven malignancies, such as inflammatory myofibroblastic tumors and neuroblastoma. However, its use may be associated with adverse effects, including gastrointestinal disturbances, hepatotoxicity, and cardiac issues, necessitating careful patient monitoring. Ongoing research explores its potential in combination therapies and broader oncological applications, solidifying its role as a key therapeutic agent in precision medicine for ALK-positive cancers.
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